Resveratrol HP and Resveratrol-Glycon HP (High Purity products)

trans-Resveratrol is a natural plant antibiotic produced by grape vines, Vitis vinifera, as a response to combat molds. As a result of pesticide use, there are presently only traces of resveratrol in red wine. trans-Resveratrol and its natural analogs are found in a number of plants; some of them are widely used in traditional Asian herbal medicine.

Recently, the New York Times (Jun. 4, 2008) commented on an article published in Public Library of Science (for abstract, see “references”). In summary, scientists from the University of Wisconsin reported a study comparing mice fed resveratrol with mice on a caloric-restricted diet and control mice on a normal diet. In the resveratrol fed mice, the same effects on gene expression, associated with heart, brain and skeletal muscle aging, were found as in the caloric-restricted mice. The researchers concluded that resveratrol can mimic many of the effects of a caloric-restricted diet and suggested that dietary consumption of resveratrol mimics caloric restriction and inhibit certain aspects of the aging process.

This new data further supports the results of a 2006 study published in the journal Nature (for abstract, see “references”) where mice were fed a high calorie fatty diet with one group also receiving a daily supplement of 22.4 mg/kg resveratrol. New York Times author Nicholas Wade wrote:

“The resveratrol did not stop them from putting on weight and growing as tubby as the other fat-eating mice. But it averted the high levels of glucose and insulin in the bloodstream, which are warning signs of diabetes, and it kept the mice's livers at normal size. Even more striking, the substance sharply extended the mice's lifetimes. Those fed resveratrol along with the high-fat diet died many months later than the mice on high fat alone, and at the same rate as mice on a standard healthy diet. They had all the pleasures of gluttony but paid none of the price.”

As there is not more than 1-3 mg t-resveratrol per liter of red wine, the daily dose used in mice for this experiment roughly corresponds to 1.7 g in man or the equivalent to consuming hundreds of liters of red wine. Most of the commercially available extracts contain only a small fraction of resveratrol or the resveratrol glycon, the remainder consisting of unidentified and/or undeclared impurities of unknown biological properties. A natural food supplement with such important properties and anti-aging effects should have a precisely defined composition. This is why a pharmaceutial grade, high purity resveratrol is needed.

Resveratrol is one of nature’s most potent free radical scavengers and antioxidants. Its antihyperlipidemic and antihypertensive effects, cholesterol lowering capabilities, salutary effects on cellular growth regulation and immune responses have been widely published in the scientific literature. The anti-aging properties of resveratrol may well be connected to the above, although specific mechanisms have been hypothesized (see “references”).

Resveratrol in its natural form is predominantly found coupled to a sugar (i.e., "glycon"), which makes the poorly soluble parent compound, trans-resveratrol, more water soluble. Also, the glycon is highly orally bioavailable and its stability is much greater compared to resveratrol without the sugar moiety (see reference Prokop et al.). Most commercial extracts are usually of low purity and contain many unidentified impurities including emodin, which in doses as low as 10 mg/day can produce diarrhea.

We are aware that the customers are increasingly concerned about the quality and safety of imported products. Our food supplements are rigorously handled under GMP (Good Manufacturing Practice) rules of the European Union and FDA. Both our HP products are certified to meet the analytical standards, for more details please see the specifications.

Resveratrol HP specifications

Resveratrol Glycon HP specifications

Our research and development facilities discovered a new technology for manufacturing high purity, pharmaceutical grade trans-resveratrol and resveratrol-glycon. Resveratrol HP and Resveratrol-Glycon HP are prepared, analyzed and certified under Good Manufacturing Practice guidelines in a plant inspected by National Regulatory Authorities. The products were approved as nutritional supplements in the Czech Republic.

Resveratrol HP and Resveratrol-Glycon HP were developed by Biophysica Research of San Diego, California and are manufactured by Interpharma Praha (www.interpharma-praha.com).